영지버섯 균주별 균사체 추출물의 항염, 항산화 및 항알러지 효능 비교 분석
Comparison of anti-inflammatory, antioxidant and anti-allergic effects of Ganoderma species mycelial extracts
(Received June 3, 2013. Accepted June 19, 2013)
Abstract
This study wascarried out to compare the medicinal effects of various Ganoderma species mycelialextracts. Among 6 Ganoderma species mycelial extracts by using 100% MeOH, G. species ASI-7150 showed the highestantioxidant effect. In nitric oxide (NO) production and β-hexosaminidase release inhibition assay, the treatment of G.lucidum ATCC64251 (Taiwan) mycelia extracts most effectively inhibited NO production in LPS-stimulated RAW264.7cells and β-hexosaminidase release. In addition, the treatment of all 6 Ganoderma species mycelial extracts were notaffect on RAW264.7 cell viability. Although this preliminary research has thrown up many questions in need of furtherinvestigation, it will serve as a base for further studies of medicinal effects of various Ganoderma species.
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2.조재한, 노형준, 강돈호, 이지영, 이민정, 박혜성, 성기호, 전창성. 2012b. 영지버섯 균쥬별 자실체의 아미노산함량 비교 분석. 한국버섯학회지 10 : 208-215.
3.Chen, J. H. and Jiang, R. L. 1980. A pharmacological study of the Chinese drug lingzhi (ganoderma). Yao Hsueh Hsueh Pao - Acta Pharmaceutica Sinica. 15 : 234-244 (in Chinese).
4.Choi Y., Kim, M. H., Shin, J. J., Park J. M. and Lee J. 2003. The antioxidant activities of the some commercial teas. J Korean Soc Food Sci Nutr 32 : 723-727.
5.Cirino, G., Distrutti, E. and Wallace, J. L. 2006. Nitric oxide and inflammation, Inflamm. Allergy. 115-119.
6.Furusawa, E., Chou, S. C., Furusawa, S., Hirazumi, A. and Dang, Y. 1992. Antitumour activity of Ganoderma lucidum, an edible mushroom, on Intraperitoneally implanted Lewis lung carcinoma in synergetic mice. Phytotherapy Research. 6 : 300-304.
7.Jiang, Z. Y. and Lin, C. 2003. Study of Ganoderma lucidum polysaccharide on effects of cellular immune function in mice. J Microbiol. 23 : 51-54.
8.Kohguchi, M., Kunikata, T., Watanabe, H., Kudo, N., Shibuya, T., Ishihara, T., et al. 2004. Immunopotentiating effects of the antlershaped fruiting body of Ganoderma lucidum (Rokkaku-Reishi). Biosci Biotechnol Biochem. 68 : 881-887.
9.Liu, Y. H., Tsai, C. F., Kao, M. C., Lai, Y. L., and Tsai, J. J. 2003. Effectiveness of Dp2 nasal therapy for Dp2-induced airway inflammation in mice: using oral Ganoderma lucidum as an immunomodulator. J Microbiol Immunol Infect. 36 : 236-242.
10.Shiao, M. S., Lee, K. R., Lin, J. J. and Wang, C. T. 1994. Phytochemicals for Cancer Prevention II, p.342. In C.T. Ho(eds), Teas, Spices and Herbs. American Chemical Society, Washington.
11.Tang, Q. J., Zhang, J. S., Pan, Y. J., Werner, R. and Fan, H. 2004. Activation of mouse macrophages by the alkaliextracted polysaccharide from spore of Ganoderma lucidum. Chin J Cell Mol Immunol. 20 : 142-144.
12.Zhang, Q. H. and Lin, Z. B. 1999. Effect of Ganoderma lucidum polysaccharides B on TNFα and INFγ production and their mRNA expression. J Beijing Med Univ. 31 : 179-183.