능이버섯의 면역 조절능
Immunomodulating activities of Sarcodon aspratus
(Received May 1, 2013. Accepted June 20, 2013)
Abstract
This study was carried out to evaluate the immunomodulatory capacity of edible mushrooms, includingSarcodon aspratus, Letinus edodes and Grifola frondosa in mice. BALB/c mice were administered 50, 500, and 1000 mg/kg body weight of various mushrooms five times a week over 4 weeks through oral administration. The control micewere administered distilled water. No significant changes in body weight were observed. IL-4 and IFN productionwas evaluated with splenic T lymphocytes stimulated in vitro with phytohemagglutinins for 48 hr. The mice groupadministered Sarcodon aspratus, Grifola frondosa tend to higher ratio of IFN versus IL-4 than the other groups. Inaddition, the ratio of plasma IgG2a versus IgG1 was also elevated in mice treated with Sarcodon aspratus. Theseresults indicated that Sarcodon aspratus can enhance type-1 helper T cell-mediated cellular immunity. And also, S.aspratus seems to be one of the most useful mushrooms for immunomedicine.
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Reference
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21.Mizuno, M, Shiomi, Y, Minato, K, Kawakami, S, Ashida, H, Tsuchida, H. 2000. Fucogalactan isolated from Sarcodon aspratus elicits release of tumor necrosis factor-α and nitric oxide from murine macrophages. Immunopharmacology. 46 : 113-121.
22.Moradali, M. F, Mostafavi, H, Ghods, S, Hedjaroude, G. A. 2007. inmmuomodulating and anticancer agents in realm of macromycetes fungi(macrofungi). Int, immunopharmacol, 7 : 701-724
23.Murata, Y, Shimamura, T, Tagami, T, Takatsuki, F, Hamuro, J. 2002. The skewing to Th1 induced by lentinan is directed through the distinctive cytokine production by macrophages with elevated intracellular glutathione content. Int Immunopharmacol. 2 : 673-689.
24.Peat, J. K, Toeile, B. G, Dermand, J, van den Berg R, Britton, W. J, Wooicock, A. J. 2008. Serum IgE levels, atopy, and asthma in young adults: results from a longitudinal cohort study. Allergy. 51 : 804-810.
25.Shao, B. M, Dai, H, Xu, W, Lin, Z. B, Gao, X. M. 2004. Immune receptors for polysaccharides from Ganoderma lucidum. Biochem Biophys Res Commun. 323 : 133-141.
26.Taguchi, T, Furue, H, Kimura, T, Kondo, T, Hattori, T, Itoh, T, Ogawa, N. 1985. End point results of phase III study of lentinan. Jp. J. Cancer Chemother. 12 : 366-380.
27.Wakshull, E, Brunke-Reese, D, Lindermuth, J, Fisette, L, Nathans, R. S. 1999. PGG-glucan, a soluble beta-(1,3)-glucan, enhances the oxidative burst response, microbicidal activity, and activates an NF-kappa B-like factor in human PMN: evidence for a glycosphingolipid beta-(1,3)-glucan receptor. Immunopharmacology. 41 : 89-107
28.Yokoyama, W. M, Kim, S, French, A. R. 2004. The dynamic life of natural killer cells. Annu Rev Immunol, 22 : 405-429.
29.Yoon, Y. H. 2004. Effect of oral administration of phellinus linteus on the productions of the Th-1 and Th-2 type cytokines in mice. Won Kwang Univ, Thesis.
2.김종봉, 이용호. 2011. 버섯첨가 두부의 면역활성에 미치는 영향. 한국식품저장유통학회지. 18 : 961-966.
3.박현지, 허용, 김종봉. 2011. 식용버섯의 면역조절에 미치는 영향. 한국생명과학회. 21 : 515-520.
4.이연희. 2007. 발아현미상황버섯이 아토피피부염에 미치는 영향. 한국미용학회지. 13 : 514-519.
5.은재순, 양재헌, 이태규, 최동성. 1989. 한국산 고등균류에 관한 연구(제 5보) 능이 중 단백분해효소의 특성과 N-말단아미노산배열. 대한약학회지 33 : 339-344.
6.이태규, 은재순, 양재헌, 조덕이, 양희천. 1989. 한국산 고등균류에 관한 연구(제3보)능이 중의 단백질 가수분해효소의 정제 및 안정성. 한국약제학회. 19 : 81-86.
7.Borchers, A. T, Stern, J. S, Hackman, R. M, Keen, C. L, Gershwin, M. E. 1999. Mushrooms, tumors, and immunity. Proc. Soc. Exp. Biol. Med. 221 : 281-293.
8.Chang, R. 1996. Functional properties of edible mushrooms. Nutr. Rev. 54 : 91-93.
9.Furue, H, and Kitoh, I. 1981. Phase 111-study on Lentinan. Jp. J. Cancer Chemother, 8 : 944-960.
10.Han, X. Q, Chai, X. Y, Jia, Y. M, Han, C. X, Tu, P. F. 2010. Structure elucidation and immunological activity of a novel polysaccharide from the fruit bodies of an edible mushroom, (Berk.)S.It. Int. J Biol. Macromol. 47 : 420424.
11.Han X. Q, Wu X. M, Cha I. X. Y, Chen, D. Dai, H, Dong, H. L, Ma, Z. Z, Gao, X. M, Tu P, F. 2011. Isolation, characterization and immunological activity of a polysaccharide from the fruit bodies of an edible mushroom, Sarcodon aspratus (Berk.) S. Ito. Food Res Int, 44 : 489-493.
12.Jeon, T. E. 2004. Bioactivities of Phellinus linteus grown on germinated brown rice. Konkuk university. Thesis.
13.Kodama N, Komuta K, Nanba H. 2003. Effect of Maitake (Grifola frondosa) D-fraction on the activation of NK cells in cancer patients. J Med Food, 6 : 371-377
14.Kodama N, Komuta K, Sakai N, Nanba H. 2002. Effects of D-fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells. Biol Pharm Bull, 25 : 1647-1650
15.Leung, D. Y. M. 2000. Atopic dermatitis:new insights and opportunities for therapeutic intervention. J Allergy Clin Immunol. 105 : 860-876.
16.Liu, Y. H, Kao, M. C, Lai, Y. L, Tsai, J. J. 2003. Efficacy of local nasal immunotherapy for Dp2-induced airway inflammation in mice: using Dp2 peptide and fungal immunomodulatory peptide. J Allergy Clin Immunol. 112 : 301-310.
17.Liu, Y. H, Tsai, C. F, Kao, M. C, Lai, Y. L, Tsai, J. J. 2003. Effectiveness of Dp2 nasal therapy for Dp2- induced airway inflammation in mice: using oral Ganoderma lucidum as an immunomodulator. J Microbiol Immunol Infect. 36 : 236-242.
18.Lull, C. Wichers, H. J, Savelkoul, H. F. J. 2005. Antiinflammatory and Immunomodulating Properties of Fungal Metabolites. Mediators of Inflammation. 2 : 63-80.
19.Manzi P, Gambelli L, Marconi S, Vivanti V, Pizzoferrato L. 1999. Nutrients in edible mushrooms: an inter-species comparative study. Food Chem. 65 : 477-482.
20.Marayuma, H. F, Yamazaki, K, Murofushi, S, Konda, C, Ikekawa, T. 1989. Antitumor activating of sarcodon asparatus (BERK)S. ITO and Ganoderma lucidum (FR). J Pharmacobio Dyn. 12 : 118-123.
21.Mizuno, M, Shiomi, Y, Minato, K, Kawakami, S, Ashida, H, Tsuchida, H. 2000. Fucogalactan isolated from Sarcodon aspratus elicits release of tumor necrosis factor-α and nitric oxide from murine macrophages. Immunopharmacology. 46 : 113-121.
22.Moradali, M. F, Mostafavi, H, Ghods, S, Hedjaroude, G. A. 2007. inmmuomodulating and anticancer agents in realm of macromycetes fungi(macrofungi). Int, immunopharmacol, 7 : 701-724
23.Murata, Y, Shimamura, T, Tagami, T, Takatsuki, F, Hamuro, J. 2002. The skewing to Th1 induced by lentinan is directed through the distinctive cytokine production by macrophages with elevated intracellular glutathione content. Int Immunopharmacol. 2 : 673-689.
24.Peat, J. K, Toeile, B. G, Dermand, J, van den Berg R, Britton, W. J, Wooicock, A. J. 2008. Serum IgE levels, atopy, and asthma in young adults: results from a longitudinal cohort study. Allergy. 51 : 804-810.
25.Shao, B. M, Dai, H, Xu, W, Lin, Z. B, Gao, X. M. 2004. Immune receptors for polysaccharides from Ganoderma lucidum. Biochem Biophys Res Commun. 323 : 133-141.
26.Taguchi, T, Furue, H, Kimura, T, Kondo, T, Hattori, T, Itoh, T, Ogawa, N. 1985. End point results of phase III study of lentinan. Jp. J. Cancer Chemother. 12 : 366-380.
27.Wakshull, E, Brunke-Reese, D, Lindermuth, J, Fisette, L, Nathans, R. S. 1999. PGG-glucan, a soluble beta-(1,3)-glucan, enhances the oxidative burst response, microbicidal activity, and activates an NF-kappa B-like factor in human PMN: evidence for a glycosphingolipid beta-(1,3)-glucan receptor. Immunopharmacology. 41 : 89-107
28.Yokoyama, W. M, Kim, S, French, A. R. 2004. The dynamic life of natural killer cells. Annu Rev Immunol, 22 : 405-429.
29.Yoon, Y. H. 2004. Effect of oral administration of phellinus linteus on the productions of the Th-1 and Th-2 type cytokines in mice. Won Kwang Univ, Thesis.