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ISSN : 1738-0294(Print)
ISSN : 2288-8853(Online)
Journal of Mushrooms Vol.11 No.4 pp.269-277

흰망태버섯 자실체의 메탄올 및 열수추출물의 항산화 및 항염증 활성

Trung Kien Nguyen1, 신도빈1, 이경림1, 신평균3, 정종천3, 유영복3, 이민웅2, 진가헌4, 김혜영5, 임경환1, 이태수1*
1인천대학교 생명과학기술대학 생명과학부, 2동국대학교, 3원예특작과학원 버섯과
4신흥대학교 안경과학과, 5신성대학교 임상병리과

Antioxidant and anti-inflammatory activities of fruiting bodies of Dyctiophora indusiata

Tae Soo Lee1*, Trung Kien Nguyen1, Do Bin Shin1, Kyung Rim Lee1, Pyung Gyun Shin3, Jong Chun Cheong3, Young Bok Yoo3, Min Woong Lee2, Ga-Heon Jin4, Hye Young Kim5, Kyung Hoan Im1
1Division of Life Sciences, Incheon National University*,(Songdo-dong) 119 Academy-ro, Yeonsu-gu, Incheon, Korea
2Department of Life Sciences, Dongguk University, 30, Pildong-ro, Seoul, 100-175, Korea
3Mushroom Division, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong 369-873, Korea
4Department of Ophthalmic Optics, Shinheung University 95 Hoam-ro, Uijeongbu, Gyeongggi 480-701, Korea
5Department of Clinical Laboratory Science, Shinsung University, Danggin 343-861, Korea
(Received December 3, 2013 / Revised December 23, 2013 / Accepted December 30, 2013)


Dictyophora indusiata is an edible mushroom belongs to Family Phallaceae of Phallales, Basidiomycota.The purpose of this study was to investigate the antioxidant and anti-inflammatory activities of methanol and hot waterextracts prepared from fruiting bodies of Dictyophora indusiata. Besides measuring of 2,2-diphenyl-1-picrylhydrazyl(DPPH) free radical scavenging activity, a reducing power and a chelating activity on ferrous ions were also measuredto evaluate the antioxidant activity for those extracts. To measure the anti-inflammatory activities for the extracts, nitricoxide(NO) production from lipopolysaccharide(LPS) treated RAW 264.7 macrophage cells and carrageenan-induced acutehind paw edema of rats were investigated. The results showed that the extracts have excellent DPPH scavenging andchelating activity on the ferrous ions compared with positive control. The nitric oxide(NO) production in LPS-stimulatedRAW 264.7 macrophage cells were decreased as we increased the concentration of the mushroom extracts. Significantreduction of paw edema of rats were observed at 2~6 h after treatment of methanol and hot-water extracts with 50 mg/kg concentration to the rats which are induced acute hind paw edema by carrageenan administration. Therefore, the experimentalresults suggested that methanol and hot-water extracts of Dictyophora indusiata fruiting bodies might be used fornatural sources of antioxidant and anti-inflammatory agents.


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