nhibitory effect of mushrooms extract on TNF-α/INF-γinduced-cytokine in human keratinocytes, HaCaT

Eun-Ju Choi, Eun-Kyung Kim¹, Yong-Seok Ji ²,Chang-Jin Lee^*

Division of Sport Science, College of Science and Technology, Konkuk University, Chungju, 380-702
¹Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University, Chungju, 380-701
²Department of Physical Education, Cheongju University, Cheongju, 363-170

^*Corresponding author, E-mail:cjlee@kku.ac.kr, Tel:+82-43-840-3496, Fax:+82-43-840-3498

Abstract

Mushroom is known for anti-inflammatory and anti-oxidative potential. This study provides evidence that theinhibitory effect of mushroom on the expression of pro-inflammatory cytokines in human keratinocytes, HaCaT cells. To definethe underlying mechanisms of action, tumor necrosis factorα/IFNγ-activated human keratinocytes model was used. Mushroomsignificantly inhibited the expression of cytokines in HaCaT cells. Taken together, the results demonstrate that mushroom inhibitedinflammtion, suggesting that mushroom (DW extract: Grifola frondosa Cordyceps militaris), (Ethanol extract: Ganoderma lucidum,Lentinus edodes, Cordyceps militaris, Flammulina velutipes) might be a candidate for the treatment of skin inflammation.

버섯류 추출물의 피부각질세포(HaCaTcell) 내염증성 사이토카인 억제효과

최은주·김은경¹·지용석²·이창진^*

건국대학교 과학기술대학 스포츠과학부
¹건국대학교 의료생명대학 식품생명과학부
²청주대학교 체육교육학과

nhibitory effect of mushrooms extract on TNF-α/INF-γinduced-cytokine in human keratinocytes, HaCaT

Abstract

버섯류 추출물의 피부각질세포(HaCaTcell) 내염증성 사이토카인 억제효과

초록

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